| Rd | Day | Date | Kick-off | Opponents | Venue |
| 1 | Saturday | 31/07/2021 | 15:00 | Edinburgh City | A |
| 2 | Saturday | 07/08/2021 | 15:00 | Stenhousemuir | H |
| 3 | Saturday | 14/08/2021 | 15:00 | Elgin City | A |
| 4 | Saturday | 21/08/2021 | 15:00 | Annan Athletic | H |
| 5 | Saturday | 28/08/2021 | 15:00 | Stirling Albion | A |
| 6 | Saturday | 11/09/2021 | 15:00 | Cowdenbeath | H |
| 7 | Saturday | 18/09/2021 | 15:00 | Kelty Hearts | H |
| 8 | Saturday | 25/09/2021 | 15:00 | Forfar Athletic | A |
| 9 | Saturday | 02/10/2021 | 15:00 | Stranraer | A |
| 10 | Saturday | 16/10/2021 | 15:00 | Elgin City | H |
| 11 | Saturday | 30/10/2021 | 15:00 | Stenhousemuir | A |
| 12 | Saturday | 06/11/2021 | 15:00 | Edinburgh City | H |
| 13 | Saturday | 13/11/2021 | 15:00 | Stirling Albion | H |
| 14 | Saturday | 20/11/2021 | 15:00 | Annan Athletic | A |
| 15 | Saturday | 04/12/2021 | 15:00 | Forfar Athletic | H |
| 16 | Saturday | 11/12/2021 | 15:00 | Kelty Hearts | A |
| 17 | Saturday | 18/12/2021 | 15:00 | Cowdenbeath | A |
| 18 | Sunday | 26/12/2021 | 15:00 | Stranraer | H |
| 19 | Sunday | 02/01/2022 | 15:00 | Edinburgh City | A |
| 20 | Saturday | 08/01/2022 | 15:00 | Stenhousemuir | H |
| 21 | Saturday | 15/01/2022 | 15:00 | Elgin City | A |
| 22 | Saturday | 22/01/2022 | 15:00 | Kelty Hearts | H |
| 23 | Saturday | 29/01/2022 | 15:00 | Cowdenbeath | H |
| 24 | Saturday | 05/02/2022 | 15:00 | Forfar Athletic | A |
| 25 | Saturday | 12/02/2022 | 15:00 | Annan Athletic | H |
| 26 | Saturday | 19/02/2022 | 15:00 | Stirling Albion | A |
| 27 | Saturday | 26/02/2022 | 15:00 | Stranraer | A |
| 28 | Saturday | 05/03/2022 | 15:00 | Edinburgh City | H |
| 29 | Saturday | 12/03/2022 | 15:00 | Kelty Hearts | A |
| 30 | Saturday | 19/03/2022 | 15:00 | Forfar Athletic | H |
| 31 | Saturday | 26/03/2022 | 15:00 | Annan Athletic | A |
| 32 | Saturday | 02/04/2022 | 15:00 | Elgin City | H |
| 33 | Saturday | 09/04/2022 | 15:00 | Stranraer | H |
| 34 | Saturday | 16/04/2022 | 15:00 | Stenhousemuir | A |
| 35 | Saturday | 23/04/2022 | 15:00 | Stirling Albion | H |
| 36 | Saturday | 30/04/2022 | 15:00 | Cowdenbeath | A |
| All fixtures subject to change |
